| Shantell | A calm and serene spirit. |
| Shaquana | A gracious, kind soul. |
| Shaquille | Derived from the Arabic name Shakil, meaning handsome. |
| Shara | A name of Hebrew origin, meaning she sings. |
| Sharongila | A name meaning a song of the forest. |
| SHARUFA | Swahili and Somali name meaning "distinguished" and "outstanding." |
| Shasa | A precious stone or jewel. |
| Shasmecka | A unique name of unknown origin. |
| Shateque | One who is honest and truthful. |
| Sheniqua | A version of the name Shanika, meaning G-d is gracious. |
| SHERMARKE | Somali name meaning "one who brings good fortune." |
| Shomari | One who is very powerful |
| Shukri | One who is grateful and thankful. |
| Sibongile | We are grateful to the Lord. |
| Sidone | A name meaning from Sidon. |
| Sika | A name meaning little deer. |
| Silko | A name meaning silk or smooth. |
| SIMBA | Swahili name popular in eastern Zaire, meaning "lion." |
| Simbarashe | A Shona name meaning power of the Lord God. |
| Sindile | One who has arrived safely. |
| SISAY | Amharic of Ethiopia unisexual name meaning "omen of good things, a blessing." |
| SISI | Akan of Ghana unisexual name meaning "born on Sunday." |
| Sitembile | One who is trusted and reliable. |
| SITI | Swahili name meaning "lady." |
| Siyanda | We are increasing in number. |
| Slam | A name meaning a forceful impact strike. |
| Sondo | A name meaning a golden treasure. |
| SRODA | Ghanaian name meaning "respect." |
| SUDI | Swahili name meaning "success" or "luck." |
| Sukarno | One who does good actions. |
| Sukutai | A sister of good nature. |
| SULE | West African name meaning "adventurous." |
| Sultan | King; A ruler / one who is bold; Sovereign. Monarch |
| Sumana | Flower; Good natured; A goodnatured woman; Wealthy |
| SUNDIATA | Guinean name meaning "hungry lion." |
| Sushaunna | Of Ethiopian origin, meaning princess. |
| Suzaan | Lelie / Lily variant of the Hebrew Susan |
| Sylvanella | A name meaning little forest dweller. |
| TABAN | Somali and Ugandan name. Meaning unknown. |
| Tabansi | one who endures |